The iPazzPort Mini Wireless "Fly Air" keyboard is a great all-in-one remote solution for your home theater PC. With it, you can put all your other remotes in a drawer except for some rarely used functions, or if you have more than two components. The "air mouse" functions similar to a Wii remote. There is also a touchpad version available, the Wireless Keyboard and Touchpad with Learning Infrared (IR) Remote, for those that would prefer a touchpad. Althuough the 2 device learning remote has a limited set of buttons, it can learn any function on your device. And if you have a HTPC or laptop connected to your TV, you really don't need a lot of functions - just on/off, volume, and channel up/down or guide for the TV, etc.
I also own the Favi Wireless Keyboard With Built-in TouchPad and Laser Pointer without the IR remote function, also by iPazzport, and also sold under a number of different brand names. I've owned it for 2 years now and it has functioned flawlessly. I paid $40 for it 2 years ago, and considered it to be a great deal at the time. (Note: the laser pointer also makes a great cat toy!)